Hemodynamics, weight and overground locomotion from 1125 rats with different spinal cord injury thoracic contusion severities recovered from the Multicenter Spinal Cord Injury Study (MASCIS)
DOI:10.34945/F5QG66
DATASET CITATION
Almeida C. A., Torres-Espin A., Huie J. Russell., Sun D., Noble-Haeusslein L. J., Young W., Beattie M. S., Bresnahan J. C., Nielson J. L., Ferguson A. R. (2021) Hemodynamics, weight and overground locomotion from 1125 rats with different spinal cord injury thoracic contusion severities recovered from the Multicenter Spinal Cord Injury Study (MASCIS). ODC-SCI:595 http://doi.org/10.34945/F5QG66
ABSTRACT
STUDY PURPOSE: Results of the process of archeological data recovery of spinal cord injury (SCI) data sets from the Multicenter Spinal Cord Injury Study (MASCIS). The goal for this subset of the MASCIS dataset was to externally validate previous fundings on the importance of peri-surgery blood pressure in long term recovery.
DATA COLLECTED: This data represents a derivative dataset that involved large scale data integration and analysis of different epochs of the MASCIS study. MASCIS is multi-site preclinical drug trial conducted in the 1990s with the primary goal of testing the efficacy of the anti-inflammatory glucocorticoid methylprednisolone, and other therapies administered acutely after an SCI in rats. The dataset contains diverse data from 1125 rats. Different groups of injury were conducted using a thoracic contusion injury model. The presented subset of the data contains summaries of blood pressure, weight and BBB scores in different injury severity groups.
DATA USAGE NOTES: This dataset constitutes a demonstration of the value of data archeology. The curation of the MASCIS study has generated this data resource that can be use for secondary analysis and further discovery.
KEYWORDS
Blood pressure; data archeology; dark data; Multicenter Animal Spinal Cord Injury Study (MASCIS)
PROVENANCE / ORIGINATING PUBLICATIONS
Carlos A. Almeida, Abel Torres-Espin, J. Russell Huie, Dongming Sun, Linda J. Noble-Haeusslein, Wise Young, Michael S. Beattie, Jacqueline C. Bresnahan, Jessica L. Nielson, Adam R. Ferguson (2021). Excavating FAIR Data: the Case of the Multicenter Animal Spinal Cord Injury Study (MASCIS), Blood Pressure, and Neuro-Recovery. Neuroinformatics. doi:http://dx.doi.org/10.1007/s12021-021-09512-z.
This publication illustrates the process of data archeology and recovery from the MASCIS study. The analysis of Blood pressure and neuro-recovery serves as use case of the potential of recovering legacy data.
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DATASET INFO
Contact: Ferguson Adam (adam.ferguson@ucsf.edu)
Lab: Ferguson Lab
ODC-SCI Accession:595
Records in Dataset: 1125
Fields per Record: 30
Last updated: 2021-03-03 (See changelog)
Date published: 2021-03-03
Downloads: 23
Files: 2
LICENSE
Creative Commons Attribution License (CC-BY 4.0)
FUNDING AND ACKNOWLEDGEMENTS
Wings for Life Foundation ARF, National Institute of Health NINDS R01NS088475 (ARF); NINDS UG3NS106899 (ARF); NIMH R01MH116156 (JLN); NCATS ULl TR002494 (JLN);, Department of Veterans Affairs 1101RX002245 (ARF); I01RX002787 (ARF), Craig H. Neilsen Foundation ARF, Original MASCIS data collection was funded by NS032000 WY
CONTRIBUTORS
- Almeida, Carlos A. [ORCID:0000-0001-9997-8719]
- Department of Neurological Surgery, Weill Institute for Neurosciences, Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA
- Torres-Espin, Abel [ORCID:0000-0002-9787-8738]
- Department of Neurological Surgery, Weill Institute for Neurosciences, Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA
- Huie, John Russell. [ORCID:0000-0001-5594-4277]
- Department of Neurological Surgery, Weill Institute for Neurosciences, Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA
- Sun, Dongming
- W.M. Keck Center for Collaborative Neuroscience, Rutgers University, New Brunswick, NJ, USA
- Noble-Haeusslein, Linda J.
- Department of Neurology, University of Texas, Austin, TX, USA; Department of Psychology, University of Texas, Austin, TX, USA
- Young, Wise
- W.M. Keck Center for Collaborative Neuroscience, Rutgers University, New Brunswick, NJ, USA
- Beattie, Michael S. [ORCID:0000-0001-9463-3631]
- Department of Neurological Surgery, Weill Institute for Neurosciences, Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA
- Bresnahan, Jacqueline C. [ORCID:0000-0003-2243-7054]
- Department of Neurological Surgery, Weill Institute for Neurosciences, Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA
- Nielson, Jessica L. [ORCID:0000-0002-3677-3959]
- Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA; Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA
- Ferguson, Adam R. [ORCID:0000-0001-7102-1608]
- Department of Neurological Surgery, Weill Institute for Neurosciences, Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA; San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA
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