ASIA Impairment Scale, level of injury, intraoperative time series mean arterial pressure and heart rate after spinal cord injury in patients in a multi-site retrospective TRACK-SCI cohort: site 1 of 2

DOI:10.34945/F5R59J

DATASET CITATION

Torres-Espin A., Haefeli J., Ehsanian R., Torres D., Almeida C., Huie J., Chou A., Dirlikov B., Suen C. G., Nielson J. L., Kyritsis N., Duong-Fernandez X., Thomas L. H., Hemmerle D. D., Morozov D., Sanderson N., Talbott J., Manley G. T., Dhall S. S., Whetstone W. D., Bresnahan J. C., Beattie M. S., McKenna S. L., Pan J. Z., Ferguson A. R. (2021) ASIA Impairment Scale, level of injury, intraoperative time series mean arterial pressure and heart rate after spinal cord injury in patients in a multi-site retrospective TRACK-SCI cohort: site 1 of 2. ODC-SCI:245 http://doi.org/10.34945/F5R59J

ABSTRACT

STUDY PURPOSE: The main goal for the collection of this data was to assess whether intraoperative hemodynamics (arterial pressure and heart rate) is associated to patient neurological improvement at hospital discharge in spinal cord injury (SCI). The data were collected in two level I trauma centers in Northern California (Santa Clara Valley Medical Center and Zuckerberg San Francisco General Hospital). This dataset represents the data from one of the centers, while the data collected in the other center is available elsewhere (see provenance). Both datasets have been harmonized, meaning variables and data dictionary align.

DATA COLLECTED: The dataset includes mean arterial pressure (MAP) and heart rate (HR) at 5 minute intervals during SCI associated surgery for n = 87 patients, as well as summaries across surgery time (average, standard deviation, kurtosis and skewness). The data also include demographics (age and gender), length metrics (surgery duration and days from injury to discharge), and injury characteristics and outcome metrics (AIS grade at admission, AIS grade at hospital discharge, dichotomized neurological level of injury: cervical vs. non-cervical).

CONCLUSIONS: Through joint analysis of both centers’ data and using machine learning methods we discovered a non-linear association of MAP during surgery and neurological improvement from hospital admission to hospital discharge. Moreover, we derived a MAP range [76-104/117mmHg] at which the longer the patient is outside that range (hypotension or hypertension) during surgery, the less likely is that the patient would have a robust neurological improvement (see the associated manuscript for further details).

KEYWORDS

Spinal Cord Injury; Intraoperative; Mean arterial pressure; Time seires; Hemodynamics; Human

PROVENANCE / ORIGINATING PUBLICATIONS

• A Torres-Espin*, J Haefeli*, R Ehsanian, D Torres, CA Almeida, JR Huie, A Chou, D Morozov, N Sanderson, B Dirlikov, CG Suen, JL Nielson, N Kyritsis, DD Hemmerle, JF Talbott, GT Manley, SS Dhall, WD Whetstone, JC Bresnahan, MS Beattie, SL McKenna, JZ Pan#, AR Ferguson# and the TRACK-SCI Investigators&. Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury. eLife 2021;10:e68015 DOI: 10.7554/eLife.68015

RELEVANT LINKS

ASIA Impairment Scale, level of injury, intraoperative time series mean arterial pressure and heart rate after spinal cord injury in patients in a multi-site retrospective TRACK-SCI cohort: site 2 of 2

https://odc-sci.org/data/246

Harmonized variables from a the second center

Surgical Blood Pressure and Expected Motor Recovery in Individuals with Traumatic Spinal Cord Injury

https://odc-sci.org/data/536

Subset of the subjects used in another different study

NOTES

DATASET INFO

Contact: McKenna Stephen (stephen.mckenna@hhs.sccgov.org)

Lab: Ferguson Lab

ODC-SCI Accession:245

Records in Dataset: 31

Fields per Record: 400

Last updated: 2021-11-17

Date published: 2021-11-17

Downloads: 36

Files: 3

LICENSE

Creative Commons Attribution License (CC-BY 4.0)

FUNDING AND ACKNOWLEDGEMENTS

NIH/NINDS grants R01NS088475 (ARF), R01NS122888 (ARF), UH3NS106899 (ARF), U24NS122732 (ARF), Department of Veterans Affairs grants 1I01RX002245 (ARF) and I01RX002787 (ARF), Wings for Life Foundation (ARF and ATE), Craig H. Neilsen Foundation (ARF), DoD grants SC150198 (MSB) and SC190233 (MSB)

CONTRIBUTORS

Torres-Espin, Abel [ORCID:0000-0002-9787-8738]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Haefeli, Jenny [ORCID:ORCID:0000-0002-3546-728X]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Ehsanian, Reza [ORCID:0000-0002-0848-2134]

Rehabilitation Research Center, Santa Clara Valley Medical Center, San Jose, CA, USA. Department of Neurosurgery, Stanford University, Stanford, CA, USA. Division of Physical Medicine and Rehabilitation, Department of Neurosurgery, University of New Mexico School of Medicine, Albuquerque, NM, USA

Torres, Dolores

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Almeida, Carlos A. [ORCID:0000-0001-9997-8719]]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Huie, J Russell [ORCID:0000-0001-5594-4277]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Chou, Austin [ORCID:0000-0003-4328-5811]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Dirlikov, Benjamin [ORCID:0000-0002-9987-5178]

Rehabilitation Research Center, Santa Clara Valley Medical Center, San Jose, CA, USA.

Suen, Cathering G.

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Nielson, Jessica L. [ORCID:0000-0002-3677-3959]

Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA; Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA

Kyritsis, Nikos [ORCID:0000-0001-7801-5796]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Duong-Fernandez, Xuan [ORCID:0000-0003-4328-5811]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Thomas, Leigh H. [ORCID:0000-0002-7593-0240]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Hemmerle, Debra D. [ORCID:0000-0003-2796-6107]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Morozov, Dmitriy

Data analytics and Visualization group, Lawrence Berkley National Lab

Sanderson, Nicole

Lawrence Berkley National Lab

Talbott, Jason [ORCID:0000-0003-3943-5530]

Zuckerberg San Francisco General Hospital and Trauma Center, Department of Radiology and Biomedical Imaging, University of California San Francisco (UCSF)

Manley, Geoffrey T. [ORCID:0000-0002-0926-3128]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Dhall, Sanjay S. [ORCID:0000-0002-6891-2722]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Whetstone, William D. [ORCID:0000-0002-8568-6640]

Department of Emergency Medicine, University of California, San Francisco, San Francisco, CA.

Bresnahan, Jacqueline C. [ORCID:0000-0003-2243-7054]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Beattie, Michael S. [ORCID:0000-0001-9463-3631]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

McKenna, Stephen L. [ORCID:0000-0003-2030-8988]

Rehabilitation Research Center, Santa Clara Valley Medical Center, San Jose, CA, USA.

Pan, Jonathan Z. [ORCID:0000-0001-5814-3707]

Brain and Spinal Injury Center, Department of Anesthesia and Perioperative Care, University of California San Francisco (UCSF)

Ferguson, Adam R. [ORCID:0000-0001-7102-1608]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Pascual, Lisa U. [ORCID:000-0001-6228-6217]

Orthopaedic Trauma Institute, Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA.

Singh, Vineeta [ORCID:0000-0003-3470-3532]

Brain and Spinal Injury Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

Burke, John F. [ORCID:0000-0002-6190-5116]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

DiGiorgio, Anthony M. [ORCID:0000-0002-5710-691X]

Brain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Weinstein, Philip R. [ORCID:0000-0003-4038-745X]

Institure for Neurodegenerative Diseases, Spine Center, Departments of Neurology and Neurological Surgery, University of California San Francisco (UCSF)