Behavior and histopathology after single-session cortical electrical stimulation and rehabilitative forelimb motor training in cervical spinal cord injury in females rats

DOI:10.34945/F59885

DATASET CITATION

Batty, N. J., Torres-Espín, A., Vavrek, R., Raposo, P., Fouad, K. (2020) Behavior and histopathology after single-session cortical electrical stimulation and rehabilitative forelimb motor training in cervical spinal cord injury in females rats. Open Data Commons for Spinal Cord Injury. ODC-SCI:458 http://doi.org/10.34945/F59885

ABSTRACT

STUDY PURPOSE:The aim of the study was to investigate the use of electrical cortical stimulation of injured corticospinal tract as a means to increase the beneficial effects of rehabilitative motor therapy after SCI in rats. The study showed that a single session of electrical stimulation of the injured fibers led to an increase in corticospinal tract (CST) plasticity, and functional recovery after training

DATA COLLECTED:Female adult Lewis rats from Charles River Laboratories, Canada, weighing 180-220 g were used for this dataset. All rats were pre-trained in the single pellet grasping (SPG) task and received a unilateral dorsal-lateral quadrant (DLQ) spinal cord transection injury at cervical vertebrae level 4 on the side of the dominant paw. n = 11 in the stimulated group, n = 9 in control. Lesion size analysis, SPG functional scores, High Speed grasp motion analysis score, CST fiber counts, Count of Significant bins in collateral CST fiber density heatmapping data

PRIMARY CONCLUSION:Electrical stimulation of injured corticospinal fibers prior to rehabilitative training can increase their plasticity and thus the effect of rehabilitative training

KEYWORDS

Spinal Cord Injury, Plasticity, Electrical stimulation, Neurite Growth, Axonal Collateral

PROVENANCE / ORIGINATING PUBLICATIONS

• Batty NJ, Torres-Espín A, Vavrek R, Raposo P, Fouad K. Single-session cortical electrical stimulation enhances the efficacy of rehabilitative motor training after spinal cord injury in rats. Exp Neurol. 2020 Feb;324:113136. Epub 2019 Nov 28. PMID: 31786212. 10.1016/j.expneurol.2019.113136.

  Originating Publication

DATASET INFO

Contact: Karim Fouad (karim.fouad@ualberta.ca)

Lab: Karim Fouad

Records in Dataset: 231

Last updated: 2020-11-17

Date published: 2020-11-17

Downloads: 20

Files: 2

LICENSE

Creative Commons Attribution License (CC-BY 4.0)

FUNDING AND ACKNOWLEDGEMENTS

CIHR PS153179 (KF)

CONTRIBUTORS

Nicholas J Batty [ORCID:0000-0001-5024-6533]

Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Abel Torres-Espín [ORCID:0000-0002-9787-8738]

University of California san Fransisco, Brain and Spinal Injury Center, dept. of Neurological Surgery; San Francisco, California, USA

Romana Vavrek [ORCID:0000-0003-1966-1258]

Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada.

Pamela Raposo [ORCID:0000-0001-6350-5223]

Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada.

Karim Fouad [ORCID:0000-0003-3654-7852]

Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada