Hemodynamic stability, incidence of pain, skin redness, autonomic dysreflexia and other safety related outcome measures of transcutaneous electrical spinal cord stimulation in children with cervical and thoracic spinal cord injuries

DOI:10.34945/F5HP4N

DATASET CITATION

Keller A. V., Singh G., Sommerfeld J., King M., Ugiliweneza B., D’Amico J., Gerasimenko Y., Behrman A. L. (2021) Hemodynamic stability, incidence of pain, skin redness, autonomic dysreflexia and other safety related outcome measures of transcutaneous electrical spinal cord stimulation in children with cervical and thoracic spinal cord injuries. ODC-SCI:465 http://doi.org/10.34945/F5HP4N

ABSTRACT

STUDY PURPOSE: This was a pilot study to establish the safety and feasibility of transcutaneous electrical spinal cord stimulation (scTS) to augment upright sitting posture and trunk control in children with spinal cord injury.

DATA COLLECTED: The primary safety-related outcome measures were assessed over the 3 days for each participant and included: hemodynamic stability assessed using brachial arm blood pressure (mmHg) and heart rate (beats per minute) at baseline (no stimulation), during stimulation, at the end of experiments and if a child presents with symptoms of autonomic dysreflexia (e.g. facial flushing, reporting of headache, etc); incidence of autonomic dysreflexia (increase in blood pressure over 20 mmHg from a previous blood pressure measurement); incidence of pain in response to stimulation (assessed using FACES Pain Scale-Revised for children under 8 and Visual Analogue Scale for children 8 and older); incidence of skin redness under the stimulating electrodes. Trunk kinematics and center of pressure displacement data are published as a separate dataset on ODC-SCI titled: "Trunk kinematic and center of pressure displacement time series data during transcutaneous lumbosacral spinal cord stimulation and passive pelvic tilt in human pediatric participants with trunk control impairments due to cervical or thoracic spinal cord injury (pilot clinical trial NCT03975634)"

CONCLUSIONS:

KEYWORDS

neuromodulation; pediatric spinal cord injury; safety; feasibility; trunk control

PROVENANCE / ORIGINATING PUBLICATIONS

• Yuanyuan Liu, Xuhua Wang, Wenlei Li, Qian Zhang, Yi Li, Zicong Zhang, Junjie Zhu, Bo Chen, Philip R. Williams, Yiming Zhang, Bin Yu, Xiaosong Gu, Zhigang He (2017) A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions. Neuron 4(95). 817-833.e4. Anastasia Keller, Goutam Singh, Joel H. Sommerfeld, Molly King, Parth Parikh, Beatrice Ugiliweneza, Jessica D’Amico, Yury Gerasimenko & Andrea L. Behrman. Noninvasive spinal stimulation safely enables upright posture in children with spinal cord injury. Nat Commun 12, 5850 (2021). DOI:10.1038/s41467-021-26026-z.

NOTES

DATASET INFO

Contact: Behrman Andrea (andrea.behrman@louisville.edu)

Lab:

ODC-SCI Accession:465

Records in Dataset:

Fields per Record:

Last updated: 2021-08-13

Date published: 2021-08-13

Downloads: 44

Files: 2

LICENSE

Creative Commons Attribution License (CC-BY 4.0)

FUNDING AND ACKNOWLEDGEMENTS

NIH/NCNM4R P2CHD086844

CONTRIBUTORS

Keller, Anastasia V. [ORCID:0000-0002-7919-8931]

University of California, San Francisco

Singh, Goutam [ORCID:0000-0002-3382-2321]

University of Louisville

Sommerfeld, Joel

University of Louisville

King, Molly

University of Louisville

Ugiliweneza, Beatrice [ORCID:0000-0001-7334-6924]

University of Louisville

D’Amico, Jessica [ORCID:0000-0002-3487-0712]

University of Louisville

Gerasimenko, Yury [ORCID:0000-0003-1229-2410]

University of Louisville

Behrman, Andrea L. [ORCID:0000-0003-1859-8787]

University of Louisville