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Dr Megan R. Detloff - Misunderstanding Macrophages: Examining DRG macrophages in SCI induced pain
Moderated by: Dr. Bethany Kondiles
Megan Detloff, PhD, is an assistant professor in the Department of Neurobiology & Anatomy at Drexel University College of Medicine. After completing her PhD at The Ohio State University under the mentorship of D. Michele Basso in 2009, she came to the College of Medicine for a postdoctoral fellowship in the laboratory of John Houlé.
Her research is focused on understanding the molecular underpinnings that contribute to the development of chronic, debilitating neuropathic pain after spinal cord injury. This pain can be described as the pain of everyday living. Normal activities like wearing a t-shirt or testing the temperature of bath water are perceived as painful. There are two active lines of research ongoing in the lab.
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Spinal cord injury (SCI) produces a complex syndrome characterized by loss of motor control and mobility; loss of bladder, bowel and sexual function; pathological pain; and loss of autonomy. The multifaceted nature of SCI presents a challenge for the translational pipeline. This problem of SCI complexity can be conceptualized as a big-data issue: the field needs a forum for large-scale data-sharing and application of advanced analytics to catalyze SCI discoveries. Various funders and publishers have recognized this need as well currently implementing data sharing mandates.
To address this challenge the SCI research community is assembling a large database through collaborative and FAIR data sharing. We are a digital infrastructure with the goal to democratize SCI data, allowing researchers to access existing SCI data, contribute their own, and publish with citable DOI. Learn more
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